GM Free Cymru

Golden Rice Feeding Trial spat

Date Added to website 4th August 2014

Golden Rice Feeding Trial spat gets even more interesting

In 2012 there was high drama when Guangwen Tang, a researcher at Tufts University, was sacked following a major spat with the Chinese authorities, relating to a feeding experiment in which Chinese children were fed Golden Rice in order to assess its effectiveness in converting beta-carotene into Vitamin A. There was no informed consent in the trials, and both parents and children were misinformed. But in 2012 the American Journal of Clinical Nutrition (AJCN) published the results of the trial, to the accompaniment of much trumpet blowing from the Golden Rice Project and the GM industry generally. Then came the Chinese protests, which escalated almost to the level of a diplomatic standoff. Chinese officials who cooperated in the trials were dismissed, and Tang's laboratory was closed.

Just when we thought this was all over, it isn't. There have been hints that the paper will soon be retracted. Retraction Watch reports that Guangwen Tang is now planning to sue AJCN if it retracts her paper, partly on the basis of "defamation." She also plans to sue Tufts University. Revenge is in the air. Interesting.....

We at GM-Free Cymru don't have much sympathy for her, since we warned her in 2008 that she was involved in unethical research, and she never even had the good grace to acknowledge receipt of our letters, let alone replying to them. The Golden Rice people live in a little cocoon, convinced of the rightness of their cause, and impervious to criticism. Their science was in this case unethical, and it sounds (from the "Nature" coverage of the scandal) as if it might have been fraudulent as well. But its also clear that Tang was hung out to dry, and that Tufts Univ and the Golden Rice Humanitarian Board were culpable as well.

Many different people were involved in designing this research, funding it and turning a blind eye to whatever skulduggery was going on. One trick was to pretend that Golden Rice is not a GMO -- or at least to fail to mention that it is........ Another ethical breach came when the much-hyped GMO was fed to humans before it had gone through any animal testing. There was zero ethical oversight, allowing the research to be conducted in a climate of secrecy and lies, and although a group of us complained to Tufts Univ in Feb 2009 our protest was arrogantly brushed aside.

Our open letter, signed by many independent scientists, and sent to Prof Robert Russell at Tufts is here:

What is amazing is that "Nature" and other science journals gave the scandal pretty big coverage. But where have our dear friends at SMC been over the past few years of Golden Rice chaos? We don't recall any in-depth "expert analysis" from its hired guns, and neither do we recall any demands for the Tang paper to be retracted. Tom Saunders, Dennis Murphy, Joe Perry, Mark Tester, David Spiegelhalter and the rest of them have, as far as I can see, maintained a thunderous silence..... strange, don't you think?


Retraction Watch

Rice researcher in ethics scrape threatens journal with lawsuit over coming retraction

with 3 comments

Guangwen Tang, a rice researcher at Tufts University, landed in hot water in 2012 after her team was accused of feeding Chinese children genetically modified Golden Rice without having obtained informed consent from the parents.

Now, she's suing both Tufts and the American Journal of Clinical Nutrition, which reportedly is retracting a paper, beta-carotene in Golden Rice is as good as p-carotene in oil at providing vitamin A to children, based on the federally funded research, claiming that the retraction would constitute defamation. (That retraction hasn't happened yet.)

This isn't the first time we've heard the retraction = defamation line. Readers might remember Ariel Fernandez, who threatened to sue us for writing about an expression of concern. Maybe a course on the Streisand Effect should be mandatory for PhD students?

According to a 2012 Nature report, the trial was chock-full of ethical missteps. Tang brought the rice into China illegally, and one of her Chinese partners faked ethics approval documents. During the study, a Chinese official emailed Tang saying he was taking mention of GMO off the consent forms, because it was too sensitive, according to reporters on China's state television channel. Three Chinese officials ended up being dismissed for violating ethics laws, and Tang received a two-year suspension from conducting human research. From Nature:

The trial was designed to test how efficiently the β-carotene is converted to the vitamin once ingested. The US study team was led by Guangwen Tang, a nutrition scientist at Tufts University in Boston, Massachusetts, and was part-funded by the US National Institute of Diabetes and Digestive and Kidney Diseases, and the US Department of Agriculture.

According to a paper published online by the American Journal of Clinical Nutrition on 1 August, each group of two dozen or so children aged six to eight ate meals containing Golden Rice, spinach or β-carotene capsules for lunch every week day during the three-week trial.

But none of the children, their parents or school teachers was aware that Golden Rice was involved, according to a 45-minute investigative news programme broadcast on 8 December on CCTV, China's state television channel.

The informed-consent form said that the rice contained β-carotene, but not that it was genetically modified or that it was Golden Rice. Nor did it highlight uncertainty around any potential risks of ingesting such rice.

After a year-long investigation, Tufts concluded that Tang had breached ethical regulations. In addition the two year human studies ban, any future research she conducts will take place under the watchful eye of a supervising scientist. From NPR:

But Tufts, after spending more than a year carrying out its own review, now says that the study was not conducted in full compliance with policy or federal regulations. According to the Tufts report, the researchers did not adequately explain the nature of golden rice and made some changes in the study without getting approval from the committee at Tufts that is supposed to review all research involving human subjects.

Here are details of the complaint, from Courthouse News Service:

After completing the research, Tang wrote a scientific article titled beta-carotene in Golden Rice is as good as p-carotene in oil at providing vitamin A to children. The American Society for Nutrition published the article in its journal in 2012.

The American Journal of Clinical Nutrition has thousands of subscribers and more than 3 million hits to its online journal site per month, according to the complaint.

Tang says the article got a lot of attention in the scientific community and has been downloaded more than 32,000 times.

Nevertheless, she claims, the American Society for Nutrition, which owns the journal and holds the copyright, told Tang that it planned to retract her article due to an investigation into her research protocol.

The university last year suspended Tang's human-subject research pending further analysis, according to the lawsuit.

Although it found no evidence of research misconduct with respect to the study, and no health or safety problems, the university told Tang she would be subject to disciplinary actions regarding future research, she claims in the complaint.

She seeks an injunction and damages for defamation, breach of contract and interference with business relations.

We can't verify Tang's claims about the popularity of her article. But it has been cited 12 times, according to Thomson Reuters Web of Science.

It's unclear if any lawsuits have been served yet, and the retraction doesn't seem to be out yet. AJCN editor Dennis Bier declined to comment, citing legal sensitivity. We've reached out to Tang's lawyer for a copy of the lawsuit, and will update with anything new we learn.